ENHANCEMENT OF THE IMMUNE IESPONSE OF CHICKENS VACCINATED WITH ADJUVANTED LIVE NEWCASTLE DISEASE VIRUS VACCINE

The poultry industry depends heavily on immunization, particularly with live attenuated vaccines. These vaccines are commonly not adjuvanted and can be either injected or delivered in birds’ mucosa. In the current study we evaluated protective efficacy of non-adjuvanted Newcastle disease virus (LaSota strain) Three NDV were used to vaccinate three groups chickens. same immunizations administered additional employing adjuvant technology where a mucosal (Montanide TM IMS 1313 nanoparticles) was used. Under experimental conditions, humoral cellular immune responses assessed, challenge test done for evaluation vaccine vaccinated RT qPCR determination viral shedding oropharyngeal swabs challenged Mucosal nanoparticles significantly improved antibody titer cell mediated response comparison ones. chicken highly virulent sub-genotype VIId at third week post vaccination, Montanide fully prevention also noticed while protection rate ranged from 90% 100% reduced. indicated that, could by using Montanide™ model delivery